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Observation of the amount of energy exhausted by patients during withdrawal from the ventilatory support in neurointensive care units.

Metabolic load changes during weaning from mechanical ventilation in neuro intensive care unit patients. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/01/061115
Enrollment
30
Registered
2024-01-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury Health Condition 2: S064- Epidural hemorrhage Health Condition 3: G700- Myasthenia gravis Health Condition 4: G94- Other disorders of brain in diseases classified elsewhere Health Condition 5: G378- Other specified demyelinating diseases of central nervous system Health Condition 6: S066- Traumatic subarachnoid hemorrhage Health Condition 7: S065- Traumatic subdural hemorrhage

Interventions

Intervention1: nil: nil Control Intervention1: nil: nil

Sponsors

National Institute of Mental Health and Neurosciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients mechanically ventilated patients in NICU (either an endotracheal tube or tracheostomy tube) who have failed the initial weaning trial and meeting the inclusion criteria during the study period. Mechanical ventilation settings (Requiring fraction of inspired oxygen (FIO2) = 50% and Positive end expiratory pressure Diagnosis: severe traumatic brain injury, aneurysmal sub arachnoid haemorrhage, Guillain-Barre syndrome, Myasthenia gravis.

Exclusion criteria

Exclusion criteria: Presence of pneumothorax, chest tubes Body temperature more than 380 C Audible air leak around endotracheal tube/tracheostomy tube Glasgow Coma Scale ( GCS Serum albumin

Design outcomes

Primary

MeasureTime frame
- To estimate the Resting energy expenditure (REE) and oxygen consumption (V ?O2) in NICU patients with difficult weaning from mechanical ventilation.Timepoint: All the study parameters will be recorded daily during the weaning trials for up to 7 days or earlier if the patient is totally of ventilator for continuous 24 hours.—

Secondary

MeasureTime frame
To assess the influence of oxygen consumption (V ?O2) on weaning ratio (WR) in patients admitted at neurocritical care units. To observe the relation between DO2/V ?O2 balance, work of breathing(WOB) and weaning outcomes. To compare the changes in REE and V ?O2 between the neurosurgical and neurological patients during difficult weaning from invasive mechanical ventilation. Timepoint: similar time points as the primary objective—

Countries

India

Contacts

Public ContactShwethashri KR

National Institue of Mental Health and Neurosciences

shwethashri.84@gmail.com9916964747

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026