Health Condition 1: O- Medical and Surgical Health Condition 2: I050- Rheumatic mitral stenosis
Conditions
Interventions
Intervention1: Intravenous Sildenafil infusion: Intravenous Sildenafil infusion intraoperative once at dose 0.07mg/kg/hr. after sternotomy
Control Intervention1: normal saline infusion: Intravenous no
Sponsors
Department of anaesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: 1.Planned to undergo mitral valve replacement surgery 2.Patient willing to give informed consent. 3.Weight between 40-70kg 4.Patient belonging to ASA grade 2 and 3 5.Ejection fraction more than 40%
Exclusion criteria
Exclusion criteria: 1.Severe hypotension on the day or before the day of surgery(SBP 2.Patients with coronary heart disease or those taking nitrates 3.Endocrine,metabolic,neurologic and psychotic disorder 4. tricuspid stenosis 5.Severe hepatic(ALT or AST >3 times the upper limit of normal) or renal dysfunction(creatinine clearance 6.Ongoing or prior malignancy. 7.History of allergy to study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Mean Pulmonary artery pressure 2.Pulmonary vascular resistance 3.Heart rate 4. Systolic diastolic and mean arterial pressureTimepoint: 1.Cardiac index 2.Central venous pressure 3.Side effects if any | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Cardiac index 2.Central venous pressure 3.Side effects if anyTimepoint: T1- before induction T2- After induction T3- after off pump T4- After 6 hours of surgery T5- After 12 hours of surgery T6-After 24 hours of surgery | — |
Countries
India
Contacts
Public ContactANJUM SAIYED
SMS MEDICAL COLLEGE
Outcome results
None listed