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comparing dexmedetomidine with lignocaine and plain lignocaine nebulization before intubation to control intubation response and hemodynamic changes.

Compare the efficacy between Nebulized dexmedetomidine with Lignocaine and plain lignocaine for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation - Randomized Control Study. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061090
Enrollment
60
Registered
2024-01-03
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: NEBULIZED DEXMEDETOMIDINE WITH LIGNOCAINE: Group A- will receive pre-operative nebulisation with Dexmeditomidine at dose of 1mcg/kg + Lignocaine at dose of 4mg/kg after that heart rate
10 minutes at base line premedication induction and intubation Control Intervention1: NEBULIZED PLAIN LIGNOCAINE: Group B-will receive pre-operative nebulisation with lignocaine at a dose of 4mg/kg
10 minutes at base line premedication induction and intubation.

Sponsors

Arpita Mohanty
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for elective surgeries under general endotracheal anaesthesia American Society of Anesthesiologists (ASA) physical status I and II Age 18-60 years Either sex

Exclusion criteria

Exclusion criteria: .ASA-III and IV .Emergency cases Predicted Difficulty Airway Obese Patients (BMI >30) Subjects On Antihypertensive Medication Pregnancy Known Allergy To Dexmeditomidine And Or Lignocaine

Design outcomes

Primary

MeasureTime frame
-To compare the efficacy of nebulised dexmeditomidine at a dose of 1mcg/kg and lignocaine 4mg/kg with the efficacy of nebulised lignocaine at a dose of 4mg/kg in attenuating the hemodynamic responses to laryngoscopy and intubation. Timepoint: 1 min,3 mins, 5 mins, 10 mins—

Secondary

MeasureTime frame
-Compare the dose sparing effect of two different nebulisation regimens on the amount of propofol consume during induction of general anesthesia. -To determine the incidence of sore throat. -To determine the incidence of perioperative nausea vomiting and cough.Timepoint: 1min, 3mins , 5mins, 10mins—

Countries

India

Contacts

Public ContactArpita Mohanty

Shri Sathya Sai Medical College and Research Institute

anusha14scorpio@gmail.com9003738506

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026