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To study the effect of statins (atorvastatin) in reducing mortality in patients of sepsis in a medical emergency setting.

Efficacy of statins in reducing the mortality in sepsis patients in a medical emergency setting- an open label parallel group Randomized control trial. - NIL

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061069
Enrollment
60
Registered
2024-01-02
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R509- Fever, unspecified

Interventions

Intervention1: ATORVASTATIN: TABLET ATORVASTATIN 20mg, per oral, once a day for 28 days in addition to standard treatment Control Intervention1: None: STANDARD TREATMENT ONLY (CONTROL GROUP) The patie

Sponsors

POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH CHANDIGARH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a) adults with age > 18 years b) Patients getting admitted in medical emergency with sepsis, defined as ?Suspected or documented infection: patient having signs and symptoms of infection, such as fever, leucocytosis, or localising signs (e.g.: pneumonia, urinary tract infection, intraabdominal infection or skin and soft tissue infection). ? SOFA score of 2 or more

Exclusion criteria

Exclusion criteria: a) Pregnant females. b) Patients of cardiovascular disease who are already on statins. c) Patients with malignancy. d) Patients with liver failure. e) Patients with myopathy. f) Age g) Patients with trauma. h) Surgical patients.

Design outcomes

Primary

MeasureTime frame
all cause mortalityTimepoint: 1month

Secondary

MeasureTime frame
organ dysfunction, length of hospital stay effect on inflammatory markers Timepoint: 1 month

Countries

India

Contacts

Public ContactDR SAURABH C SHARDA

POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH CHANDIGARH

saurabhcsharda@gmail.com01722756670

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026