Comparing two different ways of giving oxygen during surgery when the patient is not breathing

Comparison of High Flow and Low flow nasal oxygen insufflation for apneic ventilation during laryngeal surgery: A randomised controlled trial(HiFlOx Trial) - HiFlOx Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061062

Enrollment

Registered

2024-01-02

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: High Flow group: Paraoxygenation would be given using a Optiflow nasal cannula at 70l/min for the entire procedure. Control Intervention1: Low flow group: Paraoxygenation would be given

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1-2 patients undergoing tubeless laryngeal surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Severe respiratory distress requiring intubation for procedure; pregnant; active nasal bleeding; base of skull fracture

Design outcomes

Primary

Measure	Time frame
Lowest Oxygen saturationTimepoint: Baseline, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes , 10 minutes, 12 minutes, 15 minutes, 20 minutes.	—

Secondary

Measure	Time frame
end-procedure end-tidal CO2Timepoint: 1 minute after the procedure;episodes of desaturation below 90%Timepoint: Baseline, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes , 10 minutes, 12 minutes, 15 minutes, 20 minutes.;operator satisfaction scoreTimepoint: 1 minute after the procedure	—

Countries

India

Contacts

Public ContactDivya Jain

Postgraduate institute of medical education and research

jaindivya77@rediffmail.com7087008020

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026