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To observe the effect of two different drugs applied on skin in the elbow, on the veins of the arm.

Comparison of transcutaneous venous dilation effect of topical 2 % Lignocaine jelly with or without topical nitroglycerin - A randomised double blinded cross over volunteer study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061033
Enrollment
80
Registered
2024-01-01
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: NTG: NTG plus Lignocaine gel Dose 1ml (5mg) NTG solution + 1ml of 2% Lignocaine gel applied once topically on the cubital fossa. Duration of intervention 30mins Control Intervention1:

Sponsors

Mahatma Gandhi Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: - Age above 18 years of any gender - Individuals where the veins in the cubital fossa are not visible after application of tourniquet - BMI between 20 – 30 Kg/m2

Exclusion criteria

Exclusion criteria: - Refusal to participate - Any allergy to the study drugs - Skin lesions over the cubital fossa - Thrombosed or non-collapsibility of cubital fossa veins identified by USG - History of deep vein thrombosis or any other vascular disorder - History of cardiac disease or migraine headaches - Pregnant or lactating females

Design outcomes

Primary

MeasureTime frame
To compare the incidence of patients exhibiting visible vein after topical application of study drugs.Timepoint: Every 5 minutes for 30 minutes

Secondary

MeasureTime frame
1. To compare the increase in venous diameter following application of plain lignocaine gel with or without topical NTG application, measured with USG. 2. To observe the onset and duration of vein dilatation. 3. To observe any changes in the skin at site of application – redness or flushing, temperature discrimination. 4. To observe any change in haemodynamics – BP, HR after topical application of study drugsTimepoint: Every 5 mins for 30 minutes

Countries

India

Contacts

Public ContactSRUTHI K

Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth Deemed to be University

archanaareti@gmail.com8374237095

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026