Health Condition 1: N979- Female infertility, unspecified
Conditions
Interventions
Intervention1: Platelet rich plasma: Autologous intrauterine instillation of platelet rich plasma after 2 days of intrauterine insemination in case cycle
Control Intervention1: Nil: nil
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: - Diagnosed case of Unexplained infertility (documented ovulation, at least unilateral tubal patency, normal uterine cavity and normal semen analysis). - BMI: 19-25 Kg/m2
Exclusion criteria
Exclusion criteria: a) Patient on any hormonal therapy or NSAID b) Female with the diagnosis of hematological disorder and autoimmune disorder. c) Females with chronic medical disorder such as diabetes, hypertension and tuberculosis. d) Presence of active infection such Pelvic inflammatory diseases, vaginal or cervical infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Comparison of Clinical pregnancy rate with and without PRP therapy in IUI in unexplained infertility. b) Comparison of endometrial receptivity with and without PRP therapy in IUI in unexplained infertility.Timepoint: a) 15 days after IUI – UPT will be done b) 10-15 days after missed period- TVS for cardiac activity or gestational sac will be done to confirm clinical pregnancy c) Endometrial receptivity scoring will be done on the day of IUI, 2 days after IUI, and 4 days after IUI | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Comparison of luteal phase S. EGF levels with or without PRP therapy in unexplained infertility b) Correlation of endometrial receptivity with clinical pregnancy rates c) Side effects of PRP therapy in the studyTimepoint: Serum EGF levels after 4 days of IUI | — |
Countries
India
Contacts
Public ContactArchee Sinha
UCMS and GTB Hospital
Outcome results
None listed