Health Condition 1: O141- Severe pre-eclampsia
Conditions
Interventions
Intervention1: Acetylsalicylic acid (Aspirin)75 mg: Aspirin 75mg to prevent preterm pre eclampsia in women at high risk of developing pre eclampsia ,started at 12-14 weeks of pregnancy at night , ti
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Women with singleton pregnancy 12 to 16 weeks of POG who will found high risk to develop preterm preeclampsia on first trimester Quadruple test
Exclusion criteria
Exclusion criteria: Hypersensitivity to aspirin or other nsaids Active peptic ulcer disease Active bleeding in pregnancy Severe liver disease Mother on anticoagulant or anti platelet Underlying bleeding disorder in mother Fetus diagnosed with malformation or aneuploidy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Number of screen positive high risk women taking 75mg Aspirin developing preterm PE 2. Number of screen positive high risk women taking 150 mg Aspirin developing preterm PE Timepoint: At 20,24,28,30,32,34,36,37,38,39 &40 weeks of pregnancy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Fetal Abortion Preterm Birth Birth weight Stillbirth NICU admission Apgar score less than 7 Early neonatal death Intracranial bleeding 2.Maternal Intrapartum Bleeding GI bleed Gestational HT Eclampsia HELLP Abruption Acute kidney injury Mode of delivery Number of screen positive high risk women taking 75mg Aspirin developing term PE Number of screen positive high risk women taking 150 mg Aspirin developing term PE Postpartum Post partum haemorrhage HDU ICU stay Hematoma formation Mortality Timepoint: Fetai Time of delivery Maternal At 20weeks 24 weeks 28 weeks 30 weeks 32 weeks 34 weeks 36 weeks 37 weeks 38 weeks 39 & 40 weeks of pregnancy | — |
Countries
India
Contacts
Public ContactProf UPMA SAXENA
VARDHMAN MAHAVIR MEDICAL COLLEGE & SAFDARJUNG HOSPITAL
Outcome results
None listed