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Comparing osteocalcin levels in GCF after surgical management of intrabony defects with and without i-PRF for assessment of periodontal regeneration– A Pilot study

Comparative evaluation of osteocalcin levels in Gingival crevicular fluid (GCF) after surgical management of intrabony defects with and without i-PRF for real-time assessment of periodontal regeneration – A Pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/12/060963
Enrollment
72
Registered
2023-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Demineralised freeze-dried bone allograft (DFDBA) with injectable platelet rich fibrin (i-PRF): GCF samples will be taken from each patient in this group at stipulated time intervals C

Sponsors

Dr Shraddha Iyer
Lead Sponsor
Dr Sangamithra Sidharthan
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with chronic periodontitis stage III or IV, grade A 2. Interdental clinical attachment loss (CAL) of > 5 mm, probing pocket depth (PPD) of > 5 mm 3. Paired intrabony defect of > 3mm depth (including two and three walled-defects) 4. Patients undergoing guided tissue regeneration of intrabony defect (Group A and Group B). 5. Patients who are ready to give informed consent for blood withdrawal and GCF collection, and willing to undergo treatment and follow-ups.

Exclusion criteria

Exclusion criteria: 1. History of known systemic diseases like diabetes, hypertension, human immunodeficiency virus, bone disorders, immunosuppressive therapy, radiation therapy, cancer, or blood disorders. 2. Patients on medications known to affect the outcomes of periodontal therapy. 3. Patients who have undergone any surgical periodontal therapy in the preceding 6 months. 4. Pregnant or lactating mothers. Use of tobacco in any form

Design outcomes

Primary

MeasureTime frame
1. Osteocalcin levels in Group 1 (DFDBA + i-PRF) and Group 2 (DFDBA) 2. Comparison of osteocalcin levels between both groupsTimepoint: 1. Baseline 2. 1st day 3. 7th day 4. 14th day—

Secondary

MeasureTime frame
Comparison of osteocalcin levels between both groupsTimepoint: -Before surgery -1st day after surgery -7th day after surgery -14th day after surgery—

Countries

India

Contacts

Public ContactShraddha Iyer

DR. D. Y. PATIL DENTAL COLLEGE AND HOSPITAL

sangamithra.sidharthan@dpu.edu.in7721056677

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026