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Study to assess whether changes detected in pupil detected by an Automated pupillometry and changes in velocity of blood flow in brain vessels detected by Transcranial doppler have any association with occurrence of brain ischaemia following rupture of brain vessels

Study to evaluate the association of automated pupillometry and transcranial doppler with occurrence of delayed cerebral ischaemia in patients with aneurysmal subarachnoid haemorrhage - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/12/060944
Enrollment
40
Registered
2023-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Govind Ballabh Pant Institute of Postgraduate Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Aneurysmal subarachnoid haemorrhage due to anterior cerebral circulation aneurysm

Exclusion criteria

Exclusion criteria: Ocular pathology Autonomic neuropathy Concomitant use of drugs affecting PLR Unsuitable bone window for TCD examination ASA physical status V and VI Diabetes Pregnancy

Design outcomes

Primary

MeasureTime frame
Automated pupillometry derived parameter - variation of pupillary size in response to lightTimepoint: 4 hourly for the duration of stay in Neurosurgical intensive care unit—

Secondary

MeasureTime frame
1. Other automated pupillometry derived parameters a. Velocity of pupillary constriction in response to light - Constriction velocity (CV) (mm/sec) b. Time taken for initiation of reflex constriction of pupil after light stimulus – latency of reflex constriction (Lat) (millisecond) 2. TCD measured mean blood flow velocities (MFV) (cm/sec) of Middle cerebral artery (MCA), Anterior cerebral artery (ACA) and Lindegaard ratio 3. Time from pupillometry changes to DCI onset (hours) Timepoint: Automated pupillometry - 4 hourly for the duration of stay in Neurosurgical intensive care unit Transcranial doppler - 2 times a day for the duration of stay in neurosurgical intensive care unit—

Countries

India

Contacts

Public ContactAmardeep Singh

Govind Ballabh Pant Institute of Postgraduate Medical Education and Research

pganjoo@gmail.com9718599407

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026