Health Condition 1: N179- Acute kidney failure, unspecified
Conditions
Interventions
Intervention1: High Dialysate Sodium: Patients will receive hemodialysis with dialysis fluid concentration of sodium equal to 143 mEq/L
Control Intervention1: Standard Dialysate Sodium: patients will
Sponsors
KEM Hospital Research Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Acute Kidney Injury requiring SLED 2. Requirement of vasopressors or inotropes to maintain mean arterial pressure (MAP) =60 mmHg
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years 2. Patient unlikely to tolerate SLED 3. End-stage kidney disease patients 4. Patients with serum sodium less than 128 or more than 153 mEq/L at the time of randomization. 5. Patients who have received more than one session of RRT prior to randomization 6. Post neuro-surgery patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of sessions complicated with hypotensionTimepoint: day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum sodium at day 3 and day 7Timepoint: 18 months;Change in vasopressor dependency index pre and post dialysisTimepoint: 18 months;Cumulative fluid balance at day 7Timepoint: 18 months;Mortality at day 7 and day 30Timepoint: 18 months;No. of hypotension episodes per SLED sessionTimepoint: 18 months;UF volume achievedTimepoint: 18 months | — |
Countries
India
Contacts
Public ContactDr Vipul Chakurkar
KEM Hospital, Pune
Outcome results
None listed