Health Condition 1: F321- Major depressive disorder, singleepisode, moderate
Conditions
Interventions
Intervention1: MDD patients undergoing Alternate nostril Breathing: The Alternate nostril breathing protocol will be given offline to the MDD conventional therapy undergoing ANB group for 2 weeks init
5min relaxed instruction followed by 15 min of ANB protocol which will be followed by 5 min rest. The patients will be instructed to sit comfortably with the preferably spine erect. The cross-legged p
Sponsors
Indian Council of Medical Research, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults with clinically diagnosed major depressive disorder (MDD) as per DSM-V criteria 2. Either gender 3. Age between 18-45 years 4. Right-handed subjects 5. Subject should be able to give informed consent. 6. No prior exposure to yoga practices
Exclusion criteria
Exclusion criteria: H/O any psychiatric disorder other than depression 2. H/O substance abuse 3. Pregnancy 4. Chronic physical illnesses (excluded based on clinical history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Alternate Nostril breathing (ANB) will induce demarcating brain changes in MDD conventional therapy group in terms of QEEG parameters as EEG microstates (mean duration, time coverage, GEV) and Source connectivity, along with fMRI- ROL(region of interest) and network activity, which will be distinct from conventional therapy MDD group as well as the normal controls.Timepoint: 3 months after ANB | — |
Secondary
| Measure | Time frame |
|---|---|
| ANB will induce significant changes in MDD patients as compared to MDD conventional therapy patients and healthy controls in stress and inflammatory markersTimepoint: 3 months after ANB;SNB will induce significant changes in MDD patients as compared to healthy controls in EEG microstates and Sources, stress and inflammatory markersTimepoint: same day pre and post test | — |
Countries
India
Contacts
Public ContactDr Prashant Tayade
AIIMS, NEW DELHI
Outcome results
None listed