Comparison of intrapleural injection of Streptokinase and only pleural drainage in patients of pleural effusion associated with pneumonia.

Efficacy of intrapleural instillation of Streptokinase with intercoastal drainage versus intercoastal drainage alone in Stage II Parapneumonic pleural effusion - A randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060882

Enrollment

Registered

2023-12-28

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J918- Pleural effusion in other conditions classified elsewhere

Interventions

Intervention1: Injection Streptokinase instillation in intercoastal drainage tube: Instillation of injection Streptokinase 2,50,000 International units in 100ml normal saline, done intrapleurally thro

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients over the age of 18 years of either gender. 2. Patients having moderate to massive stage II parapneumonic pleural effusions.

Exclusion criteria

Exclusion criteria: 1. Patient not giving consent. 2. Patients having malignant pleural effusions. 3. Patient having pleural effusion with a history of trauma. 4. Patients having Hemothorax, frank empyema, hydropneumothorax and pyopneumothorax. 5. Bleeding disorder or anticoagulant therapy.

Design outcomes

Primary

Measure	Time frame
Effect of Streptokinase in resolving loculated parapneumonic effusions.Timepoint: On admission, 48hours after Streptokinase instillation and at the time of intercoastal drainage tube removal.	—

Secondary

Measure	Time frame
1. To study the complications related to intrapleural instillation of Streptokinase: a. Anaphylactic reaction b. Rash c. Worsened dyspnea d. Intrapleural bleeding 2. To study the overall duration of hospital stay in patients of intrapleural instillation of Streptokinase with Intercoastal Drainage versus Intercoastal Drainage alone in stage II Parapneumonic pleural effusionsTimepoint: From Instillation of Streptokinase to the date of discharge	—

Measure

Time frame

1. To study the complications related to intrapleural instillation of Streptokinase: a. Anaphylactic reaction b. Rash c. Worsened dyspnea d. Intrapleural bleeding 2. To study the overall duration of hospital stay in patients of intrapleural instillation of Streptokinase with Intercoastal Drainage versus Intercoastal Drainage alone in stage II Parapneumonic pleural effusionsTimepoint: From Instillation of Streptokinase to the date of discharge

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Countries

India

Contacts

Public ContactRajasi Bundale

NKP Salve Institute of Medical Sciences & Research Centre and Lata Mageshkar Hospital

anilsontakke66@gmail.com9869027857

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026