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Purpose of this study is to compare the effect of two different anesthetic regimen (Etomidate alone or Etomidate with Ketamine) that will be used to induce loss of consciousness in patients (in order to alleviate the pain and agony during surgery) on alteration of Serum Cortisol levels

Effect of adding ketamine to etomidate infusion on serum cortisol levels for anesthetic induction compared to etomidate infusion alone in elective surgical patients: a randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/12/060851
Enrollment
80
Registered
2023-12-27
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K31- Other diseases of stomach and duodenum

Interventions

Intervention1: Etomidate and Ketamine combined infusion: Ketamine solution will be prepared by mixing 2mL of ketamine (50mg/mL) with 8mL normal saline. The infusion will be prepared in a 20mL syringe

Sponsors

Jawaharlal Institute of Postgraduate Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients aged 18-60 years posted for elective surgeries undergoing general anaesthesia 2)ASA class 1 & 2

Exclusion criteria

Exclusion criteria: 1)Pregnant and lactating women 2)Patients belonging to NYHA class 3&4 3)Known case of adrenal insufficiency 4)Known case of seizure disorder 5)Patients on steroid therapy 6)Patients who may require intraoperative or postoperative steroids

Design outcomes

Primary

MeasureTime frame
To compare the changes in the serum cortisol levels after giving the allotted drugs (Etomidate or Etomidate and Ketamine)Timepoint: To compare the changes in the serum cortisol levels at baseline and after giving the allotted drugs (Etomidate or Etomidate and Ketamine) at 4hrs, 12hrs, and 24hrs.—

Secondary

MeasureTime frame
The time required for serum cortisol level to return to pre-induction rangeTimepoint: The time required for serum cortisol level to return to pre-induction range by comparing the serum cortisol level measured at baseline,4hrs, 12hrs & 24hrs post induction;To compare the reduction in the etomidate dose requirement during induction of anesthesia between the two groups (Etomidate or Etomidate & Ketamine)Timepoint: To compare the reduction in the etomidate dose requirement during induction of anesthesia between the two groups (Etomidate or Etomidate & Ketamine) which is measured at the time of induction—

Countries

India

Contacts

Public ContactJency

Jawaharlal Institute of Postgraduate Medical Education and Research

munaganuri1975@yahoo.co.in9786184626

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026