A study to evaluate the effectiveness of Dexmedetomidine vs Lignocaine 4% nebulization in decreasing the stress response of laryngoscopy

Effectiveness of Dexmedetomidine vs Lignocaine 4% nebulization to attenuate haemodynamic response during laryngoscopy - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060744

Enrollment

120

Registered

2023-12-26

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H619- Disorder of external ear, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine is a potent, highly selective a-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. The patient

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade 1 and 2

Exclusion criteria

Exclusion criteria: Emergency operations Uncontrolled systemic disease Obese individuals Anticipated difficult intubation

Design outcomes

Primary

Measure	Time frame
To evaluate the Effectiveness of Dexmedetomidine and Lignocaine 4% nebulization in attenuating hemodynamic response during laryngoscopy. Laryngoscopy and Intubation responses result in increased circulatory catecholamines, heart rate (HR), blood pressure, myocardial oxygen demand, and dysrhythmias. The rise in HR and blood pressure is usually transient, variable, and unpredictable.Timepoint: To evaluate hemodynamic status (Pulse rate, blood pressure, MBP, Spo2), Ramsay sedation score in time points of 2 mins, 5 mins, 10 mins, 15 mins and 20 mins after intubation	—

Measure

Time frame

To evaluate the Effectiveness of Dexmedetomidine and Lignocaine 4% nebulization in attenuating hemodynamic response during laryngoscopy. Laryngoscopy and Intubation responses result in increased circulatory catecholamines, heart rate (HR), blood pressure, myocardial oxygen demand, and dysrhythmias. The rise in HR and blood pressure is usually transient, variable, and unpredictable.Timepoint: To evaluate hemodynamic status (Pulse rate, blood pressure, MBP, Spo2), Ramsay sedation score in time points of 2 mins, 5 mins, 10 mins, 15 mins and 20 mins after intubation

—

Secondary

Measure	Time frame
1. To compare intra-operative hemodynamic parameters (HR, SBP, DBP, MAP) in both groups. 2. To determine the level of sedation 3. To evaluate any intra or post-operative adverse effects of the drug Timepoint: To evaluate hemodynamic status, Ramsay sedation score in time points of 2 mins, 5 mins, 10 mins, 15 mins and 20 mins after intubation	—

Countries

India

Contacts

Public ContactDr Farhan Moosani

Pandit Deendayal Upadhyay Medical College and Civil Hospital, Rajkot

drvandanapithadia@yahoo.com9898090220

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026