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A scientific experiment to study the attenuation of intubation response with dexmeditomedine nebulization & sublingual nitroglycerin spray

Attenuation of hemodynamic response to laryngoscope & endotracheal intubation with preinduction dexmeditomedine nebulization versus sublingual nitroglycerin spray in patients undergoing elective surgeries - a prospective randomised comparative study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/12/060709
Enrollment
100
Registered
2023-12-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group D: Nebulization with dexmeditomedine 1 µg/kg diluted to 5ml of normal saline 30 minutes before induction of anaesthesia Control Intervention1: Group N: Sublingual nitroglycerin sp

Sponsors

Department of Anesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age group 18 - 60 years Both genders ASA grade I and II

Exclusion criteria

Exclusion criteria: Patient refusal Pregnancy Emergency surgery Patient with anticipated difficult airway Modified mallampatti III and IV Laryngoscope and intubation time >20s Obese patients with BMI >30kg/m2 H/o chronic hepatic renal or cardiac disease H/o drug allergy

Design outcomes

Primary

MeasureTime frame
Attenuation of intubation response with dexmeditomedine nebulization versus sublingual nitroglycerin sprayTimepoint: Baseline At induction 1 min after induction 2 min after induction 3 min after induction At intubation 1 min after intubation 2 min after intubation 3 min after intubation 5 min after intubation 10 min after intubation 15 min after intubation 30 min after intubation At extubation 5 min after extubation 10 min after extubation 15 min after extubation 20 min after extubation 25 min after extubation 30 min after extubation—

Secondary

MeasureTime frame
Adverse effects of dexmeditomedine and nitroglycerinTimepoint: 24 hours—

Countries

India

Contacts

Public ContactDr Hemalatha S

Mysore Medical College and Research Institute

vijayanagaraj@yahoo.co.in9886239622

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026