The study compares two treatment methods for improvement in pain and function in osteoarthritis of knee

Effectiveness of fluoroscopy guided cryoablation of genicular nerves in comparison with steroid and local anaesthetic block in improving pain and function in patients with grade 3 and 4 osteoarthritis of knee: A randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060703

Enrollment

Registered

2023-12-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Fluoroscopy guided cryoablation of genicular nerves: Patient positioning and monitoring will be identical to the diagnostic nerve block procedure. After disinfection and sterile skin pr

Eligibility

Inclusion criteria

Inclusion criteria: 1. Persons with osteoarthritis of the knee as per 2016 revised ACR criteria for early diagnosis of osteoarthritis 2. Osteoarthritis of the knee with Kellgren Lawrence grade 3,4 3. Duration of symptoms more than 3 months 4. Age 40 to 70 years 5. VAS = 4 6. Positive diagnostic block ( >50% improvement in pain) 7. Willingness to participate in the study and comply with treatment and follow up

Exclusion criteria

Exclusion criteria: 1. Acute knee injury/pain 2. Prior knee surgery 3. Serious neurologic/psychiatric disorder/cognitive impairment 4. Intra articular injection with steroids/hyaluronan in the last 3 months 5. Recent myocardial infarction or stroke 6. Uncontrolled diabetes and hypertension/systemic diseases 7. Coagulation disorder 8. Local or systemic infections 9. Allergy to anaesthetic medication (Lignocaine and Bupivacaine) and steroids used

Design outcomes

Primary

Measure	Time frame
Knee pain measured by VAS Timepoint: At the end of 1st week, 4th week 12th week, and 24th week	—

Secondary

Measure	Time frame
Functional outcome by WOMAC score.Timepoint: At the end of 1st week, 4th week 12th week, and 24th week	—

Countries

India

Contacts

Public ContactLongjam Nilachandra Singh

Regional Institute of Medical Sciences

drnilalong@gmail.com7005018045

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026