Study of effects of different amounts of drug called Dexmedetomidine which helps in reducing stress response like increasing blood pressure, heart rate, coughing etc when patients get a breathing tube removed after having laparoscopic surgery to remove their gallbladder.

A comparative study of two infusion doses of Dexmedetomidine for alleviating stress response to tracheal extubation in patients undergoing laparoscopic cholecystectomy - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060691

Enrollment

Registered

2023-12-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Dexmedetomidine: -Loading dose of Dexmedetomidine 0.5 µg per kg diluted to 10ml ( Duration : over period of 10 mins before starting of the infusion) -Dexmedetomidine 0.3 µg per kg pe

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I & II patients undergoing Laparoscopic Cholecystectomy

Exclusion criteria

Exclusion criteria: - Those on ß-blockers, Digoxin, Alpha 2-adrenergic agonists or psychotropic medications - Patients with Heart Rate below 60 per min or Blood Pressure less than 100 mmHg systolic and less than 60 mmHg diastolic - Patients with a history of allergic reactions to drug used in study. - Patients who required postoperative mechanical ventilation - Pregnant or nursing woman - Morbidly obese patients - ASA Grade III & IV patients - Anticipated difficult intubation.

Design outcomes

Primary

Measure	Time frame
- Haemodynamic changes during tracheal extubation - Airway response using 5 point scale during tracheal extubationTimepoint: During extubation	—

Secondary

Measure	Time frame
- Time taken for emergence & tracheal extubation - Evaluation for presence of complications such as laryngospasm, bronchospasm, delayed recovery, respiratory depression, & bradycardiaTimepoint: During extubation	—

Countries

India

Contacts

Public ContactDr. Naseem Akhtar

Medanta Abdur Razzaque Ansari Memorial Weavers Hospital

Naseem.Akhtar@medanta.org9955577739

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026