To compare the effect of fall in blood pressure by nitroglycerin and labetalol in patients undergoing functional endoscopic sinus surgery.

Comparative Effect of Hypotension Induced by Nitroglycerin Versus Labetalol On Serum Lactate Level In Patients Undergoing Funtional Endoscopic Sinus Surgery: A Randomized Interventional Study at SMS Medical College Jaipur - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060596

Enrollment

Registered

2023-12-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj. Nitroglycerin: Inj. Nitroglycerin with a starting dose of 0.5ml/kg/h to have starting dose of 0.5 mcg/kg/min followed by an infusion of 0.5- 2mcg/kg/min through infusion pump.The i

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective functional endoscopic sinus surgery 2. Patients of either sex willing to give consent 3. Age group of 18 to 45 years. 4. ASA grade I & II

Exclusion criteria

Exclusion criteria: 1. History of allergy to any of the study medication 2. Patient with pre-existing bleeding and coagulation abnormalities 3. Patients with diabetes, hypertension, cardiovascular disease 4. Cerebrovascular disorders 5. Renal and hepatic impairment

Design outcomes

Primary

Measure	Time frame
1. To determine and compare the serum lactate levels at different time intervals between the groups. 2. To determine and compare peripheral perfusion index between the two groups.Timepoint: 120 minutes	—

Secondary

Measure	Time frame
1. To determine and compare the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) at different time intervals between the groups. 2. To compare the quality of intra-operative surgical field score by using a categorical scale in both the groups (0-5). 3. To compare the intra operative blood loss between the two groups.Timepoint: 120 minutes	—

Measure

Time frame

1. To determine and compare the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) at different time intervals between the groups. 2. To compare the quality of intra-operative surgical field score by using a categorical scale in both the groups (0-5). 3. To compare the intra operative blood loss between the two groups.Timepoint: 120 minutes

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Countries

India

Contacts

Public ContactDr Priyanka P Nair

Sawai Man Singh Medical College And Attached Hospitals

drmamtasharma@hotmail.com9829566077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026