A clinical trial to compare the effects of 3 drugs - Dexmeditomedine, Ketamine and Preservative free lignocaine in reducing the pain caused by injection of propofol

"Comparison of intravenous pretreatment with dexmeditomedine, ketamine and preservative free lignocaine in alleviating propofol injection pain -- A prospective randomized study." - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060528

Enrollment

150

Registered

2023-12-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: PROPOFOL: 25% of the calculated dosage of propofol will be administered to the patient over a period of 60 seconds before induction of anaesthesia Control Intervention1: DEXMEDITOMEDINE

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who are willing to participate in the study 2. Patients undergoing surgeries that require general anaesthesia with propofol as induction agent 3. Age group of 18-60 of either sex 4. American society of anaesthesiologist (ASA) physical status I and II

Exclusion criteria

Exclusion criteria: 1.History of drug allergy 2.Patients who dont fit in the age/ ASA criteria 3.History of psychiatric disorder 4.History of seizure disorder 5.History of substance abuse

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of intravenous dexmeditomedine ,ketamine and preservative free lignocaine in reducing the Intensity of pain upon injection of propofol graded on a four point scale (0-3) None (0) - No response to questioning Mild (1) - Pain reporting in response to questioning only Moderate (2) - Pain reporting in response to questioning and or pain reported spontaneously without questioning Severe (3) - Strong vocal response accompanied by facial grimace, arm withdrawals or tearsTimepoint: 0 seconds, 30 seconds and 60 seconds	—

Measure

Time frame

To compare the efficacy of intravenous dexmeditomedine ,ketamine and preservative free lignocaine in reducing the Intensity of pain upon injection of propofol graded on a four point scale (0-3) None (0) - No response to questioning Mild (1) - Pain reporting in response to questioning only Moderate (2) - Pain reporting in response to questioning and or pain reported spontaneously without questioning Severe (3) - Strong vocal response accompanied by facial grimace, arm withdrawals or tearsTimepoint: 0 seconds, 30 seconds and 60 seconds

—

Secondary

Measure	Time frame
The hemodynamic variability in patients upon injecting these study agents.Timepoint: 0 seconds and 1 minute	—

Countries

India

Contacts

Public ContactDr Shivanandha PT

Shimoga Institute of Medical Sciences

shivananda1233@gmail.com9986327599

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026