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Comparison of phenylephrine with mephentermine in prevention of oxytocin induced vitals changes in caesarean section under spinal anaesthesia

Comparison of phenylephrine with mephentermine in prevention of oxytocin induced hemodynamic changes in caesarean section under spinal anaesthesia: randomized controlled trial ? - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/12/060498
Enrollment
64
Registered
2023-12-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O94-O9A- Other obstetric conditions, not elsewhere classified

Interventions

Intervention1: Phenylephrine 75mcg: Phenylephrine Will be given after delivery of baby simultaneously with oxytocin. Control Intervention1: Mephentermine 6 mg: Mephentermin Will be given after deliver

Sponsors

ROHILKHAND MEDICAL COLLEGE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.American society of Anaesthesiologist (ASA) grade II. 2.Females between 18 -40 years of age

Exclusion criteria

Exclusion criteria: 1.Patient allergic to local anaesthetics. 2. ASA >II 3. Baseline heart rate less than 60 per minute 4. Baseline blood pressure than 100/60 mmHg. 5. Bleeding diathesis and coagulopathy. 6. Septic Shock.

Design outcomes

Primary

MeasureTime frame
. To evaluate the efficacy of phenylephrine in treating oxytocin induced hemodynamic changes in patients undergoing spinal anaesthesia for caesarean section. 2. To evaluate the efficacy of mephentermine in treating oxytocin induced hemodynamic changes in patients undergoing spinal anaesthesia for caesarean section. 3. To compare efficacy of phenylephrine and mephentermine in treating oxytocin induced hemodynamic changes in patients undergoing spinal anaesthesia for caesarean section. Timepoint: Just after delivery of baby and after cord clamping oxytocin 3 IU iv bolus over 1 min was administered and hemodynamic effects of oxytocin were studied. Heart rate , MAP, SBP,DBP were studied every 1 minute for next 5 mins.—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactDr. ANKUR GARG

ROHILKHAND MEDICAL COLLEGE

umapurohit58@gmail.com9927004515

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026