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To compare the effect of esmolol and lidocaine on middle cerebral artery during emergence from anaesthesia

A comparative analysis of the effect of single dose esmolol and lidocaine on Middle cerebral artery velocity(MCA) during emergence from anaesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/12/060488
Enrollment
90
Registered
2023-12-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K807- Calculus of gallbladder and bile duct without cholecystitis Health Condition 2: H701- Chronic mastoiditis Health Condition 3: G55- Nerve root and plexus compressionsin diseases classified elsewhere Health Condition 4: K469- Unspecified abdominal hernia without obstruction or gangrene

Interventions

Intervention1: Comparision of drugs effect on middle cerebral artery velocity and hemodynamic parameters during emergence from surgery: C1)ESMOLOL Group: inj. Esmolol 1.5mg/kg Intravenously 2)LIDOCA

Sponsors

Department of Anaesthesiology and Critical Care Jawaharlal Nehru Medical college AMU Aligarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Physical status of ASA I & II 2) Mallampati score class I & II

Exclusion criteria

Exclusion criteria: 1) Physical status of ASA III & IV 2) Those with significant systemic disorder 3) Those with uncontrolled hypertension and cerebrovascular disease 4) Those with co-morbid disease 5) Allergy to local anaesthetic and those on beta- blocker therapy Pregnant female

Design outcomes

Primary

MeasureTime frame
Effect of esmolol and lidocaine on Middle cerebral artery velocity during emergence from anaesthesiaTimepoint: 1) T0- During anaesthesia 2) T1- before administration of drugs (when train of four response is more than 90%) 3) T2- After two minute of administration of drug 4) T3- After three minutes of extubation—

Secondary

MeasureTime frame
1. To analyse and compare the effect of esmolol and lidocaine on hemodynamic parameters e.g systolic blood pressure(SBP), heart rate(HR) during emergence from anaesthesia 2. To correlate the change in hemodynamic parameters (SBP, HR) with MCA velocity during emergence from anaesthesia 3. Any adverse effect e.g hypotension, bradycardia, cough, bronchospasm, laryngospasmTimepoint: 1) T0- During anaesthesia 2) T1- before administration of drugs (when train of four response is more than 90%) 3) T2- After two minute of administration of drug 4) T3- After three minutes of extubation—

Countries

India

Contacts

Public ContactDr LHINGNEILAM HAOKIP

JAWAHARLAL NEHRU MEDICAL COLLEGE , AMU

obaidahmad2008@gmail.com9897695761

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026