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Quantifying biomarkers in patients with cleft lip/cleft palate undergoing fixed mechanotherapy

Quantifying micro-RNA 223 and heme-oxygenase during orthodontic tooth movement in patients with cleft lip/cleft palate undergoing fixed mechanotherapy: a prospective, cohort study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/12/060486
Enrollment
20
Registered
2023-12-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Fixed mechanotherapy in Group A i.e. Unilateral Cleft Lip/Cleft Palate: Fixed Orthodontic Treatment will be initiated and saliva will be collected at various time points Control Interve

Sponsors

Manav Rachna International Institute of Research and Studies
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with unilateral cleft lip and palate 12-18 years Both sexes Non syndromic No other congenital abnormalities No history of previous orthodontic treatment

Exclusion criteria

Exclusion criteria: Individuals having cleft lip and palate with any syndromes, congenital disorders. Individuals with systemic diseases affecting bone density Previous orthodontic intervention Bilateral CLCP patients

Design outcomes

Primary

MeasureTime frame
To compare the miR-223 & Hmox expressed in salivary fluid in CL/CP patients and healthy patients during fixed mechanotherapy.Timepoint: Baseline: T0 7th day: T1 14Tth day: T2 30th day: T3 60th day: T4—

Secondary

MeasureTime frame
To compare these biomarkers at the end of the treatmentTimepoint: at the end of the treatment—

Countries

India

Contacts

Public ContactDr Nikita Mohelay

Manav Rachna Dental College

drpuneetbatra@gmail.com9810335961

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026