Objective versus standard pain management during surgeries

qNOX guided versus standard care intraoperative analgesia during fentanyl-propofol anaesthesia in patients undergoing laparoscopic and robotic intraabdominal surgeries- a non inferiority RCT - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060457

Enrollment

Registered

2023-12-04

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R108- Other abdominal pain

Interventions

Intervention1: qNOX guided intraoperative fentanyl administration: This is a non inferiority RCT. one group will receive q NOX guided fentanyl and other group will receive conventional fentanyl admini

Eligibility

Inclusion criteria

Inclusion criteria: Patients of ages 18 years to 70 years of either sex belonging to ASA I to III and Scheduled to undergo elective laparoscopic and robotic intraabdominal surgeries under general anaesthesia expected to last >2 hours

Exclusion criteria

Exclusion criteria: i. Patients requiring TIVA for nerve monitoring ii. Patients who do not have regional or neuraxial blocks iii. If a different intraoperative opioid than fentanyl is preferred by doctors. iv. Patients with neurologic conditions who also use psychotropic medications that may make it difficult to accurately estimate postoperative pain v. Chronic opioid user vi. BMI > 40 kg/m2 vii. Refusal to give consent

Design outcomes

Primary

Measure	Time frame
Comparing the total opioid requirement in intraoperative period and in first hour of post operative period after extubation in patients receiving qNOX-guided fentanyl titration versus those receiving conventional fentanyl administrationTimepoint: Opioid given during intraoperative period; during first 60 min in post op	—

Secondary

Measure	Time frame
i. To compare the pain scores (0-10 Verbal Response Scale) after extubation in patients receiving qNOX guided fentanyl titration versus those receiving conventional fentanyl administration ii. Time for emergence from anesthesia—the time between the end of inhalational anaesthesia and extubation iii. Modified Aldrette Score at every 30 minutes iv. Side effects: like nausea, vomiting,Timepoint: post operative pain scores (VAS) and modified aldrette score in the first hour of post operative period	—

Measure

Time frame

i. To compare the pain scores (0-10 Verbal Response Scale) after extubation in patients receiving qNOX guided fentanyl titration versus those receiving conventional fentanyl administration ii. Time for emergence from anesthesia—the time between the end of inhalational anaesthesia and extubation iii. Modified Aldrette Score at every 30 minutes iv. Side effects: like nausea, vomiting,Timepoint: post operative pain scores (VAS) and modified aldrette score in the first hour of post operative period

—

Countries

India

Contacts

Public ContactDR Teena Gupta

All India Institute of Medical Sciences Jodhpur

geethamanoj007@yahoo.co.in9414084584

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026