Comparison of Two Type of Blood Derivatives (A-PRF) And (L-PRF) On Wound Healing After Surgical Removal Of Lower Third Molar in Terms of Pain, Restricted Mouth Opening, Swelling and Wound Healing.

Comparison Of The Efficacy Of Advanced Platelet-Rich Fibrin (A-PRF) And Leukocyte – Platelet-Rich Fibrin (L-PRF) On Post Operative Pain, Swelling, Trismus And Soft Tissue Wound Healing After Removal Of Impacted Mandibular Third Molar: A Randomized Controlled Trial. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060450

Enrollment

Registered

2023-12-04

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: A-PRF: local delivery in the extraction socket of surgically removed impacted mandibular third molar A-PRF is placed once in the extraction socket and left in situ Control Intervention1

Eligibility

Inclusion criteria

Inclusion criteria: Patients between age of 18-45 years of both genders. Patients indicated for surgical removal of impacted mandibular third molar. Healthy patients falling under ASA I and ASA II Subjects willing to provide written informed consent and compliant with study procedure.

Exclusion criteria

Exclusion criteria: Patients with mouth opening less than 30mm. Patient with allergy with NSAIDS. Patients having history of drug abuse. Patients having any systemic or local infection. Patient is under analgesics and anti-depressants. Having any blood coagulation impairment. Having previous history of radiation therapy in the head and neck region. Pregnant and nursing women. Patient with the history of smoking and alcohol. Soft tissue impactions. Presence of any acute oral infection. Patients who are immune-compromised or having immunodeficiency.

Design outcomes

Primary

Measure	Time frame
Pain Facial swelling Trismus Timepoint: Postoperative assessments for pain, trismus and swelling will be performed on 1st, 3rd and 7th day	—

Secondary

Measure	Time frame
Wound healingTimepoint: wound healing assessment will be done on 1st , 3rd, 7th and 15th day postoperatively	—

Countries

India

Contacts

Public ContactDr Siddhant Tiwari

Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur

drshallubansal@gmail.com9116155666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026