Health Condition 1: A170- Tuberculous meningitis
Conditions
Interventions
Intervention1: AZATHIOPRINE: 2 months of daily oral isoniazid (5mg/kg of body weight, max 300mg) + rifampicin (10mg/kg, max 600mg)+ pyrazinamide (25mg/kg, max 2g/day) + i.m. streptomycin (20mg/kg, max
daily oral dose for following 4 weeks as 4, 3, 2, 1 mg/day on weeks 5, 6, 7, 8 respectively)for 2 months+Azathioprine(started at 1 mg/kg followed by uptitration to 2mg/kg at 1 month followup and then
daily oral dose for following 4 weeks as 4, 3, 2, 1 mg/day on weeks 5, 6, 7, 8 respectively) for 2 months
Sponsors
Department of Neurology King George Medical University
Eligibility
Inclusion criteria
Inclusion criteria: • All consecutive newly diagnosed patients of tuberculous meningitis, fulfilling the consensus diagnostic criteria as described by Marais et. Al. • Patients are categorized into definite, probable or possible tuberculous meningitis group on the basis of clinical, imaging and laboratory criteria. • DEFINITE CASES- either have acid fast bacilli in CSF or mycobacterium could be cultured from CSF or CSF is positive for mycobacterial nucleic acids by PCR. • PROBABLE CASES- they fulfill the clinical entry criteria plus a total diagnostic score of 10 or more points (when neuroimaging is absent) OR 12 or more points (when neuroimaging is present) plus excision of alternative diagnosis. • POSSIBLE CASES- clinical entry criteria plus a total diagnostic score of 6-9 points (when neuroimaging is not available) OR 6-11 points (when neuroimaging is available) along with the exclusion of alternative diagnosis.
Exclusion criteria
Exclusion criteria: 1. Patients with cryptococcal meningitis or any other cause for meningitis will be excluded. 2. Patients with having baseline deranged liver function tests, kidney function tests, pregnancy & lactation will be excluded. 3. Patients who do not give consent will be excluded. 4. Age 80 years 5. HIV Positive status
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Paradoxical Reaction in Tuberculous meningitisTimepoint: Baseline, 1 month, 3 months & 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of disability (as per Modified Barthel Index) in patients with Tuberculous MeningitisTimepoint: 6 MONTHS;Mortality in patients with Tuberculous MeningitisTimepoint: 6 MONTHS | — |
Countries
India
Contacts
Public ContactSaritesh Kumar Thakur
King George Medical University, Lucknow
Outcome results
None listed