Role of probiotics intake on the disease course of arthritis in children.

Effect of probiotics supplementation on disease activity in juvenile idiopathic arthritis: A double blind randomised controlled trial - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/12/060403

Enrollment

Registered

2023-12-01

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M08- Juvenile arthritis

Interventions

Intervention1: Probiotics: Capsule containing Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Bifidobacterium Longum will be used as supplements for a period of 3 months in the study group. Contro

Eligibility

Inclusion criteria

Inclusion criteria: Children with polyarthritis below 16 years will be included in the study. The diagnosis of polyarthritis will be established by criteria laid down by International League Association for Rheumatology (ILAR)

Exclusion criteria

Exclusion criteria: Children with diarrhea, exposure to antibiotics, and history of regular curd consumption in the previous 6 weeks will be exempted from participating in the study.

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of regular probiotic intake on the disease activity in juvenile idiopathic arthritis. Timepoint: The disease activity will be assessed by using Juvenile Disease Activity Score 10 (JADAS10) at 6 weeks 10 weeks 16 weeks, and end of the study.	—

Secondary

Measure	Time frame
To evaluate the impact of regular probiotic intake on the gut microbiota in children with juvenile idiopathic arthritis.Timepoint: Gut microbiota of 15 cases of juvenile idiopathic arthritis & 15 controls will be assessed at the beginning & end of the study (1st week & at 20 weeks) by metagenome sequencing of stool samples.	—

Countries

India

Contacts

Public ContactDr Pratap Kumar Patra

All India Institute of Medical Sciences

drpratapkp@aiimspatna.org7766932165

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026