Nalbuphine versus Paracetamol for post operative analgesia in patients undergoing percutaneous nephrolithotomy under general anaesthesia

A prospective randomised double blind Study of comparison of intravenous nalbuphine versus intravenous paracetamol for post operative analgesia in patients undergoing percutaneous nephrolithotomy under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060331

Enrollment

Registered

2023-11-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N202- Calculus of kidney with calculus of ureter

Interventions

Intervention1: Intravenous injection Nalbuphine: Administering the study drug intravenous injection nalbuphine o.2mg/kg body weight 30 minutes before extubation Control Intervention1: Intravenous inje

Eligibility

Inclusion criteria

Inclusion criteria: Normal adult patients aged between 18 years to 50 years of both genders weighing 50-70 kg who were posted for elective PCNL surgeries under general anaesthesia. Patients belonging to ASA grade 1 and ASA grade 2 .

Exclusion criteria

Exclusion criteria: Age 50 years . Patients with history of allergy to either Nalbuphine or paracetamol. Patients with uncontrolled diabetic and hypertensive patients. Patients with cardiac , hepatic and cerebral diseases. Patients with history of coagulopathies , hypothyroidism, hyperthyroidism, pregnant ladies and lactating mothers. Patients with difficult airway and obese patients, BMI >30 .

Design outcomes

Primary

Measure	Time frame
To assess pain severity and time and dose of rescue analgesic requirements after administration of intravenous Nalbuphine versus intravenous Paracetamol in patients undergoing PCNL surgeries under general anaesthesiaTimepoint: 24 hours	—

Secondary

Measure	Time frame
To study changes in hemodynamic parameters, heart rate , systolic blood pressure, diastolic blood pressure, mean arterial pressure, respiratory rate at various intervals postoperatively . To study any adverse effects associated with iv Nalbuphine and I’ve Paracetamol administration.Timepoint: 24 hours	—

Countries

India

Contacts

Public ContactShalini A

Mysore medical college and research institute

shalinianand20@gmail.com9986061614

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026