Health Condition 1: K802- Calculus of gallbladder without cholecystitis Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Propofol: Intravenous Propofol (10 mg/ml) of dose titrated to achieve a BIS value of 40-50 will be given at the time of induction of Anesthesia.
Control Intervention1: Thiopentone: Intr
Sponsors
Pt BD Sharma PGIMS, Rohtak
Eligibility
Inclusion criteria
Inclusion criteria: ASA grade I & II. Posted for elective surgery under general anaesthesia.
Exclusion criteria
Exclusion criteria: Anticipated difficult bag mask ventilation (history of snoring, obesity, large tongue, tonsillar hypertrophy, edentulous and presence of beard etc) and difficult airway (mouth opening less than 3 cm, MPG grade 3 and 4, TMD less than 6.5 cm, restricted neck movements and inability to extend the lower incisor beyond upper incisor) Pregnant patient BMI more than 30 kg/m2 Respiratory disease, increased risk of aspiration Requiring awake intubation History of allergy to study drugs Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of static and dynamic compliance during bag mask ventilation after induction with thiopentone and propofol.Timepoint: 30 sec after achieving clinical end point of induction with thiopentone / propofol and till 30 sec after that (TI, TI1, TI2, TI3, TI4, TI5, TI6 i.e. 30s, 35s, 40s, 45s, 50s, 55s & 60s after induction respectively) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare and assess 1. Peak inspiratory pressure (PIP) and plateau pressure (PP) at induction & after muscle relaxant (MR) 2. Ratio of expiratory and inspiratory tidal volume (VTe / VTi) after induction & MR 3. Compliance during bag mask ventilation after MR 4. Ease of mask ventilation (Han’s grading scale) 5. Any other adverse effects (bronchospasm, increase airway pressure, hypertension, hypotension, bradycardia, tachycardia, desaturation)Timepoint: 150 sec after giving relaxant and till 30s after that (TM, TM1, TM2, TM3, TM4, TM5, TM6 i.e. 150s, 155s, 160s, 165s, 170s, 175s, 180s after muscle relaxant respectively) | — |
Countries
India
Contacts
Public ContactDr Anurag Das
Pt B D Sharma PGIMS, Rohtak
Outcome results
None listed