To study the effect of anesthesia drugs ketamine and dexmeditomidine mixture on nerve monitoring and pain during spinal surgery: A comparison with propofol

Effect of ketodex infusion on transcranial motor evoked potentials in spinal instrumentation surgery: A comparative study with propofol - not applicable

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060318

Enrollment

Registered

2023-11-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M472- Other spondylosis with radiculopathy Health Condition 2: M472- Other spondylosis with radiculopathy

Interventions

Intervention1: Ketadex ( ketamine and dexmedetomidine in the ratio 1:2): Ketamine 100 mg in 50 ml saline Dexmeditomidine 200 mcg in 50 ml saline Net effective concentration 2 mg ketamine per ml and 4

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I and II Lower extremity power more than 3 in MRC scale

Exclusion criteria

Exclusion criteria: Refusal to consent Lower extremity power less than 3 in MRC scale Morbid obesity ASA grade III or more Opioid dependent or addict

Design outcomes

Primary

Measure	Time frame
1.Effect of Ketadex infusion on TcMEPs 2. Effect of Ketadex infusion on TcMEPs 3. Effect of Ketadex infusion on hemodynamic parameters intraoperatively Timepoint: 1. Hemodynamic parameters( heart rate, systolic diastolic and mean BP) every 15 minutes 2. TcMEPs at baseline and during major surgical intervention including instrumentation 3. Postoperative pain at 0, 2,4,6,8,10 hours 4. Need for rescue analgesia	—

Measure

Time frame

1.Effect of Ketadex infusion on TcMEPs 2. Effect of Ketadex infusion on TcMEPs 3. Effect of Ketadex infusion on hemodynamic parameters intraoperatively Timepoint: 1. Hemodynamic parameters( heart rate, systolic diastolic and mean BP) every 15 minutes 2. TcMEPs at baseline and during major surgical intervention including instrumentation 3. Postoperative pain at 0, 2,4,6,8,10 hours 4. Need for rescue analgesia

—

Secondary

Measure	Time frame
Effect of ketadex infusion on postoperative painTimepoint: Postoperative pain at 0, 2,4,6,8,10 hours	—

Countries

India

Contacts

Public ContactDr Sourav Burman

Institute of Neurosciences Kolkata

wowsourav@gmail.com8447448791

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026