A study to assess the thoracic epidural anaesthesia effects on pancreatic blood flow, thereby controlling disease progression in pancreatitis patients in comparison to standard care alone

Effect of thoracic epidural anaesthesia on pancreatic perfusion as compared to standard care alone in patients with moderately severe acute pancreatitis- a randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060287

Enrollment

Registered

2023-11-28

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K859- Acute pancreatitis, unspecified

Interventions

Intervention1: Thoracic epidural anaesthesia using Bupivacaine in moderately severe acute pancreatitis patients: Patients with moderately severe acute pancreatitis will undergo perfusion CT scan, then

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients with moderately severe acute pancreatitis admitted in JIPMER casualty within 48 hours of symptoms onset. Enrollment will be based on Modified Marshal Scoring for organ dysfunction. This score is based on - Respiratory parameter – PaO2/FiO2 - Renal parameter – Serum creatinine - Cardiovascular parameter- systolic BP Each parameter will be given 0- 4 scores based on the values. A score of =2 in any one of the systems signifies organ dysfunction.

Exclusion criteria

Exclusion criteria: -Acute pancreatitis patients with coagulopathies, spine deformities, raised intracranial pressure, refractory hypotension, and skin infections at the site of injection. -Patients with acute on chronic pancreatitis -Pancreatitis patients with evidence of sepsis -Patients with previous episodes of acute pancreatitis -Patients with CKD whose GFR <30ml/min/BSA

Design outcomes

Primary

Measure	Time frame
To assess the effect of thoracic epidural anaesthesia on pancreatic perfusion based on perfusion CT in moderately severe acute pancreatitisTimepoint: Before induction of thoracic epidural anaesthesia After giving thoracic epidural anaesthesia for 5 days	—

Secondary

Measure	Time frame
-To assess the liver and renal perfusion based on perfusion CT in severe acute pancreatitis -To assess the organ dysfunction in severe acute pancreatitis -To study the morbidities in severe acute pancreatitis patients -To assess the ventilator free days, duration of hospital stay and 30 day mortality in moderately severe acute pancreatitis -To assess the analgesic effect of TEA on pain score -To correlate organ perfusion with the biomarkers – serum Intestinal fatty acid binding protein (I-FABP), serum Liver fatty acid binding protein (L-FABP) and urine Neutrophil gelatinase associated lipocalin (N-GAL) on intestinal, liver and renal perfusion respectively Timepoint: Before induction of thoracic epidural anaesthesia After giving thoracic epidural anaesthesia for 5 days	—

Measure

Time frame

-To assess the liver and renal perfusion based on perfusion CT in severe acute pancreatitis -To assess the organ dysfunction in severe acute pancreatitis -To study the morbidities in severe acute pancreatitis patients -To assess the ventilator free days, duration of hospital stay and 30 day mortality in moderately severe acute pancreatitis -To assess the analgesic effect of TEA on pain score -To correlate organ perfusion with the biomarkers – serum Intestinal fatty acid binding protein (I-FABP), serum Liver fatty acid binding protein (L-FABP) and urine Neutrophil gelatinase associated lipocalin (N-GAL) on intestinal, liver and renal perfusion respectively Timepoint: Before induction of thoracic epidural anaesthesia After giving thoracic epidural anaesthesia for 5 days

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Countries

India

Contacts

Public ContactDr Shanmugam

Jawaharlal Institute of Postgraduate Medical Education and Research

dharmatamil06@gmail.com9940366806

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026