Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10 DCR, World Health Organization, 1993). 2.Age between 18- 60 years of either sex. 3.Minimum of 1 failed antipsychotic trial specified (minimum two weeks trial with chlorpromazine equivalents of >600 mg/day) and mean number of failed trials not reported. 4.A score >3 in the global rating of auditory hallucinations on the SAPS scale. 5.Right handed. 6.Patients giving written informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of co-morbid neurological or other psychiatric disorder(s). 2.Patient with co-morbid substance dependence, except nicotine and caffeine and having used the substance within 1 month of imaging. 3.Having any metallic implants/parts in body. 4.Subjects who have received ECT in past 6 months. 5.Patients having a history of head trauma with loss of consciousness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. difference in the levels of N-Acetyl Aspartate (NAA), N-Acetyl Aspartyl Glutamate (NAAG), Creatine + Phosphocreatine (Cr + PCr), Glycerophosphocholine + Phosphocholine (GPC + Pecha) and Myo-inositol (mI) in mPFC of schizophrenia patients with persistent Auditory-Verbal Hallucinations (pAVH) compared to healthy adults.Timepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in the resting-state functional connectivity of Default Mode Network between schizophrenia patients with pAVH & healthy controls.Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactDr Umesh S
Central Institute of Psychiatry
Outcome results
None listed