Effect of carbon dioxide on depth of anesthesia in patients undergoing thyroidectomy.

Evaluation of the effect of hypercarbia versus normocarbia on depth of anesthesia at MAC-bar of sevoflurane concentration in patients undergoing thyroidectomy. - nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060239

Enrollment

Registered

2023-11-24

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Hypercarbia: Patient blood carbon dioxide will be allowed to increase to 40-45 mmHg and the BIS and hemodynamic variables will be noted till 5 minutes after incision. Control Interventi

Eligibility

Inclusion criteria

Inclusion criteria: ASA I or II patients, Patients undergoing thyroidectomy with incision approximately more than 10cm.

Exclusion criteria

Exclusion criteria: History of anesthetic allergy, History of chronic pain, Alcohol or drug abuse, Preoperative medication use that might influence sympathetic responses to surgical incision like betablockers

Design outcomes

Primary

Measure	Time frame
BIS indexTimepoint: At 1 minute after surgical incision	—

Secondary

Measure	Time frame
1. To study the effect of hypercarbia versus normocarbia on depth of anesthesia as reflected in BIS monitoring at MAC-bar concentration of sevoflurane at 1 minute min before and 5 minutes after surgical incision at same volatile anesthetic concentration during thyroidectomy surgeries.Timepoint: 1 minute before and 5 minutes after incision.;Correlation between arterial partial pressure of carbon dioxide (PaCO2) and end tidal carbon dioxide(ETCO2) at 5 minutes after surgical incision.Timepoint: At 5 minutes after surgical incision.;To compare the hemodynamic response between patients with hypercarbia and normocarbia at MAC-bar of sevoflurane to surgical incision.Timepoint: 1 minute before incision, 1 minute after incision and 5 minutes after incision.	—

Measure

Time frame

1. To study the effect of hypercarbia versus normocarbia on depth of anesthesia as reflected in BIS monitoring at MAC-bar concentration of sevoflurane at 1 minute min before and 5 minutes after surgical incision at same volatile anesthetic concentration during thyroidectomy surgeries.Timepoint: 1 minute before and 5 minutes after incision.;Correlation between arterial partial pressure of carbon dioxide (PaCO2) and end tidal carbon dioxide(ETCO2) at 5 minutes after surgical incision.Timepoint: At 5 minutes after surgical incision.;To compare the hemodynamic response between patients with hypercarbia and normocarbia at MAC-bar of sevoflurane to surgical incision.Timepoint: 1 minute before incision, 1 minute after incision and 5 minutes after incision.

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Countries

India

Contacts

Public ContactAiswarya P Suresh

AMRITA INSTITUTE OF MEDICAL SCIENCES

drjerrypaul@gmail.com7907258837

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026