Health Condition 1: A91- Dengue hemorrhagic fever
Conditions
Interventions
Intervention1: Plasmalyte: Children in PL/NS/RL group will be started with 10-20ml/kg bolus of study fluid(4,6) in initial 30 mins, if the hematocrit falls, pulse rate and blood pressure stable and ur
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Children suffering from dengue shock syndrome (DSS) will be enrolled. DSS will be defined as DHF as well as hypotension, tachycardia, narrow pulse pressure (less than/equal to 20 mmHg) and signs of poor perfusion (e.g cold extremities, delayed capillary filling time, feeble pulses). Dengue Haemorrhagic Fever (DHF) will be defined as a child fulfilling clinical criteria of dengue fever with bleeding tendencies viz., petechiae, ecchymoses or purpura, positive tourniquet test and/or skin, mucosal or gastrointestinal bleed with thrombocytopenia ( 20% increase in haematocrit, >20% decrease in haematocrit after fluid therapy, pleural effusion, ascites, hypoproteinemia).
Exclusion criteria
Exclusion criteria: 1) Children already received fluids from outside before enrolment in last 6 h 2) Children with cardiogenic shock 3) Known patient with chronic kidney disease as per KDIGO. 4) Severe malnutrition defined as per WHO. 5) Children whose parents deny consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| = 5mmol/L increase in serum chloride level within 48 hours (h) post-randomization.Timepoint: Baseline, 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| hospital stay duration, need for colloid bolus, incidence of hyponatremia (serum sodium less than 135 mmol/L in the first 48 h of fluid management), new-onset AKI, standard base excess, serum lactate levels, renal replacement therapy, organ dysfunction (25)and serum magnesium levels.Timepoint: first 48 hours, during hospital stay | — |
Countries
India
Contacts
Public ContactVidushi Mahajan
Government Medical College and Hospital Chandigarh
Outcome results
None listed