a study on combined benefits of probiotics and desloratadine as compared to desloratadine alone in chronic spontaneous urticaria – An open labelled randomized controlled trial at a tertiary care centre in Central India

Probiotics as an adjunct therapy to desloratadine as compared to desloratadine alone in chronic spontaneous urticaria – An open labelled randomized controlled trial at a tertiary care centre in Central India

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060134

Enrollment

Registered

2023-11-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L501- Idiopathic urticaria

Interventions

Intervention1: Group A (Desloratadine plus probiotic): Group A will receive probiotic capsule (containing not less than 2.5 billion cells of Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidob

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age of patients greater than or equal to 18 years with chronic spontaneous urticaria.

Exclusion criteria

Exclusion criteria: 1.Pregnancy, lactation 2.Co-morbidities like (autoimmune disorders, cardiovascular, neurological, hepatic, renal or malignant diseases) 3.Patients who have received corticosteroids, immunosuppressants, NSAIDs or antibiotics in past 4 weeks. 4.Patients having history of acute gastrointestinal illness such as indigestion and mal-absorption. 5.Patients having history of acute angioedema with respiratory distress. 6.Patients who are not willing to participate.

Design outcomes

Primary

Measure	Time frame
Patients treated with probiotic plus desloratadine will have better reduction in UCT7, AECT and DLQI as compared to the patients treated with desloratadine alone.Timepoint: Baseline, 2 weeks and 4 weeks	—

Secondary

Measure	Time frame
Patients treated with both probiotic plus desloratadine( Group A) will require less up-dosing of desloratadine as compared to the ones treated with desloratadine alone (Group B) at 2 weeksTimepoint: 2 weeks	—

Countries

India

Contacts

Public ContactPatel Prachi Chetankumar

AIIMS, Raipur

ripuneel@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026