comparison of low dose clonidine and dexmedetomidine as a supportive agent to levobupivacaine in spinal anaesthesia

comparative evaluation of low dose intrathecal clonidine and dexmedetomidine as an adjuvant to levobupivacaine in subarachnoid block - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060123

Enrollment

Registered

2023-11-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: levobupivacaine clonidine and dexmedetomidine: comparative evaluation of low dose intrathecal clonidine 15 mcg and dexmedetomidine 10 mcg initially as an adjuvant to levobupivacaine in

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient scheduled for surgery under subarachnoid block 2.Age 18-60 years 3.Both genders 4.ASA grade I and II

Exclusion criteria

Exclusion criteria: 1.Morbid obesity BMI >30kg permeter square 2.Patient with history of adverse response to study drugs 3.Patient with pre-existing neurological or spinal disease cardiovascular disease renal hepatic or any other systemic disease 4.Pregnant females 5.Coagulopathy or bleeding diathesis

Design outcomes

Primary

Measure	Time frame
To compare the effect of low dose intrathecal clonidine versus dexmedetomidine as anadjuvant to 0.5 percentage hyperbaric levobupivacaine in subarachnoid block in respect to 1.To compare the time of onset & duration of sensory blockade assessed by pinprick & Visual Analog Score VAS respectively. 2.To compare the time of onset & duration of motor blockade assessed by modified Bromage scale Timepoint: Post operative period	—

Measure

Time frame

To compare the effect of low dose intrathecal clonidine versus dexmedetomidine as anadjuvant to 0.5 percentage hyperbaric levobupivacaine in subarachnoid block in respect to 1.To compare the time of onset & duration of sensory blockade assessed by pinprick & Visual Analog Score VAS respectively. 2.To compare the time of onset & duration of motor blockade assessed by modified Bromage scale Timepoint: Post operative period

—

Secondary

Measure	Time frame
Changes in vitals parameters heart rate noninvasive blood pressure & oxygen saturation SPo2 2. Requirementoffirst analgesicrescueinpostoperativeperiodin thefirst 24hours. Timepoint: Post operative perriod	—

Countries

India

Contacts

Public ContactDr Manish Kumar Agarwal

School of Medical Sciences and Research Sharda University Greater Noida

dr.manishagarwal09@gmail.com09838706199

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026