A study to compare efficacy of IPL with topical Tretinoin therapy vs topical Tretinoin therapy alone in facial acne vulgaris

A split face clinical trial to compare efficacy of topical Tretinoin 0.025% with & without intense pulse light 530nm filter in Indian young adult patients of grade 2 &3 facial acne vulgaris with Fitzpatrick phototype IV-VI - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060111

Enrollment

Registered

2023-11-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: Intense pulsed light 530nm filter: A test patch will be done on left post-auricular area at minimal fluence of 12J/cm2 for phototype 6, 15J/cm2 for phototype 5 and 18J/cm2 for phototype

Eligibility

Inclusion criteria

Inclusion criteria: Age greater than 18 years Grade 2-3 facial acne vulgaris at department of dermatology at tertiary care hospital, who are willing to give informed written consent to participate in study

Exclusion criteria

Exclusion criteria: History of photosensitivity History of taking photosensitizing drug Pregnancy Within 1 year post-partum Unable to follow up for IPL sessions

Design outcomes

Primary

Measure	Time frame
Mean percentage reduction in global acne grading scale (GAGS), absolute lesion count of inflammatory papule and pustules will be calculated and compared on both sides of face i.e. side which is treated with IPL 530nm with topical Tretinoin 0.025% cream and other side which is treated with topical Tretinoin 0.025% cream alone.Timepoint: Outcome will be assessed at each session i.e. at baseline, 1 month, 2 months, 3 months, 4 months.	—

Measure

Time frame

Mean percentage reduction in global acne grading scale (GAGS), absolute lesion count of inflammatory papule and pustules will be calculated and compared on both sides of face i.e. side which is treated with IPL 530nm with topical Tretinoin 0.025% cream and other side which is treated with topical Tretinoin 0.025% cream alone.Timepoint: Outcome will be assessed at each session i.e. at baseline, 1 month, 2 months, 3 months, 4 months.

—

Secondary

Measure	Time frame
NATimepoint: NA	—

Countries

India

Contacts

Public ContactDr Vedashri Ghatbandhe

TNMC and BYL Nair charitable hospital

vedaghatbandhe1709@gmail.com9029495590

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026