A clinical trial to study and compare the effect of dexmedetomidine and magnesium sulphate along with combination of Paracetamol, Tramadol, Lignocaine to assess hemodynamic stability and post operative recovery in patients undergoing surgery under general anaesthesia

A prospective randomised study to compare pre-emptive use of combination of Paracetamol, Tramadol, Lignocaine and Dexmedetomidine versus combination of Paracetamol, Tramadol, Lignocaine and Magnesium sulphate to assess hemodynamic stability and post operative recovery in patients undergoing surgery under general anaesthesia - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/060082

Enrollment

Registered

2023-11-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K20-K31- Diseases of esophagus, stomach and duodenum Health Condition 2: K261- Acute duodenal ulcer with perforation

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine 50µg along with paracetamol 1gm, inj. lignocaine (preservative free) 1.5 mg/kg, inj. tramadol 50 mg and in form of infusion over 15 minutes befo

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 physical status scheduled for elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Refusal to give consent or Patient for whom any drug from the combination is contraindicated.

Design outcomes

Primary

Measure	Time frame
To assess intraoperative hemodynamic stability in terms of change in heart rate and mean arterial pressure.Timepoint: Heart rate and mean arterial pressure monitoring will be done at 15 minutes interval till end of surgery	—

Secondary

Measure	Time frame
To compare Ease of extubation, Post operative recovery, total duration of analgesiaTimepoint: Ease of extubation, Post operative recovery, total duration of analgesia will be noted at the end of surgery	—

Countries

India

Contacts

Public ContactDr Deepali Valecha

Mahatma Gandhi Memorial Medical College, Indore

deepalisidhwani@gmail.com9424405405

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026