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A clinical study to evaluate the fluid response in patients undergoing neurosurgery.

Short-time low peep challenge test to predict fluid responsiveness during spine surgery in the prone position with low tidal volume ventilation: A prospective observational study. - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/11/060081
Enrollment
52
Registered
2023-11-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

AIIMS NEW DELHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All elective patients (Between 18 to 70 years of age), classified as ASA I or II, are scheduled for spine surgery in the prone position, and receiving ventilation with low tidal volume.

Exclusion criteria

Exclusion criteria: o ASA >III o Any recurrent cardiac arrhythmia; reduced ventricular systolic function (ejection fraction o BMI of more than 30 kg/m2 o Chronic lung disease o Chronic kidney disease o Pre-operative use of beta-blocking agents

Design outcomes

Primary

MeasureTime frame
To evaluate the reliability of short-term low PEEP challenge (SLPC)-induced decrease in stroke volume index (â?? SVI- SLPC) to predict fluid responsiveness in patients undergoing spine surgery with lung-protective ventilation in the prone position.Timepoint: Starting Point: Five minutes after the adoption of the prone positioning with hemodynamic stability. End Point: Three minutes after the administration of fluid loading.—

Secondary

MeasureTime frame
â?¢ To compare the predictability of this method (â??SVI-SLPC) with that of traditional dynamic indices (SVV & PPV) to predict fluid responsiveness. â?¢ To determine appropriate best cut-off values over the receiver operator characteristics (ROC) curve. â?¢ To assess the correlation between (â??SVI-SLPC) & changes in SV induced by volume expansion (â??SV-VE). Timepoint: Starting Point: Five minutes after the adoption of the prone positioning with hemodynamic stability. End Point: Three minutes after the administration of fluid loading.—

Countries

India

Contacts

Public ContactDr Niraj Kumar

ALL INDIA INSTITUTE OF MEDICAL SCIENCES (AIIMS) NEW DELHI

drnirajaiims@gmail.com09013770806

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026