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Vitamin D and Liver Health in North India

A randomised controlled trial of vitamin D supplementation on leukocyte telomerase length and telomerase activity in obese Individuals from north Indian with non-alcoholic fatty liver disease. - VITD-NAFLD

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/11/060045
Enrollment
160
Registered
2023-11-21
Start date
Unknown
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Vitamin D Supplementation: • Appropriate diet and physical activity counseling. • Supplementation with Vitamin D and oral Calcium-Doses of cholecalciferol (commercial name, Calcirol) 6

Sponsors

Indian Council of Medical Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age 18-60 years Body Mass Index ( >25 Kg/m2) NAFLD by ultrasound Baseline level of 25 hydroxy vitamin D

Exclusion criteria

Exclusion criteria: a) Known case of diabetes mellitus. b) Known case of HIV infection. c) On any medication within last one month which could potentially influence insulin secretion, insulin sensitivity, vitamin D or calcium metabolism (eg metformin, thiazolidione, steroids etc) and on any medication that activate steroid and xenobiotic receptor and drugs used in transplantation (e.g. steriods, calcitonin etc.) d) Severe end organ damage or chronic diseases: renal/ hepatic failure, any malignancy, nephrotic syndrome, malabsorption etc. e) Primary or tertiary hyperparathyroidism, granulomatous disorders (e.g. sarcoidosis) and any lymphomas

Design outcomes

Primary

MeasureTime frame
Vitamin D supplementation could Increase/preserve leucocyte telomerase length and activity, thus having positive effects on ageing. Timepoint: Vitamin D supplementation could Increase/preserve leucocyte telomerase length and activity, thus having positive effects on ageing will be assessed at enrolment time and after 6 month intervention.—

Secondary

MeasureTime frame
Vitamin D supplementation could decreased lipids, metabolic parameters, anthropometry and body fat measurements.Timepoint: Glycemic and lipid profile, metabolic parameters, body composition [Dual-energy X-ray absorptiometry (DXA)] will be assessed at enrolment time and after 6 month intervention.;Vitamin D supplementation could Improve insulin action and glucose physiology, leading to lowering of blood glucose levels in persons with prediabetes.Timepoint: Blood glucose and insulin levels will be be assessed at enrolment time and after 6 month intervention.—

Countries

India

Contacts

Public ContactDr Ranveer Singh Jadon

AIIMS, New Delhi

rsjadonaiims@gmail.com9540951048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026