Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Control Intervention1: Anti Xa & aPTT values at 3 different time intervals comparison: Study Group already on LMWH will be administered their last dose of enoxaparin at night on the day prior to their
Sponsors
AIIMS, Bhopal
Eligibility
Inclusion criteria
Inclusion criteria: 1)To be on prophylactic dose of Inj. Enoxaparin at the time of presentation for elective surgery 2)Must be able to accurately report the timing of their last dose and the administered dosage. 3)Patients must also be between the ages of 18-80 years of age 4) Must be able to give written consent to participate.
Exclusion criteria
Exclusion criteria: 1) Factors known to interfere with aPTT monitoring such as lupus anticoagulant disease, clotting factor deficiencies (factor V, VIII, IX, X, XI, XII and von Willebrand disease), severe liver disease, acquired vitamin K deficiency, antithrombin (AT) III deficiency, elevated levels of clotting factors, pregnancy and increased factor VIII level. 2) Patients who are receiving enoxaparin as a bridge from another anti-Xa inhibiting medication will be excluded as this could unpredictably affect the results of anti-Xa testing. These medications include: Apixaban, Edoxaban, Fondaparinux, and Xarelto.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Anti-Xa activity levels at 10hours ,12 hours & 14 hours after prophylactic dose of Enoxaparin. 2.aPTT values at 10 hours, 12 hours & 14 hours after prophylactic dose of Enoxaparin Timepoint: 10hours ,12 hours & 14 hours after prophylactic dose of Enoxaparin. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Relationship between anti-Xa/aPTT and patients age 2. Relationship between anti-Xa/aPTT and patients weight 3. Relationship between anti-Xa/aPTT levels and patients gender 4. Relationship between anti-Xa/aPTT levels and patients comorbidities. Timepoint: preoperative | — |
Countries
India
Contacts
Public ContactHarish Kumar
All India Institute of Medical Sciences, Bhopal
Outcome results
None listed