Comparative study of intravenous norepinephrine and mephentermine for maintenance of blood pressure during spinal anaesthesia for caesarean section.

Randomised double-blind comparative study of intravenous norepinephrine and mephentermine for maintenance of blood pressure during spinal anaesthesia for caesarean section : At department of anaesthesia, S.M.S. Medical College and attached group of hospitals, Jaipur - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059993

Enrollment

Registered

2023-11-20

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O748- Other complications of anesthesiaduring labor and delivery

Interventions

Intervention1: Maintenance of blood pressure during spinal anaesthesia: Maintenance of blood pressure during spinal anaesthesia by using intravenous norepinephrin 8 micrograms bolus doses and intraven

Eligibility

Inclusion criteria

Inclusion criteria: 1.Elective lower segment caesarian section who have given written and informed consent. 2.Age group- 18-35 years. 3.ASA (American Society Of Anaesthesiologist) grade one and grade two. 4.Weight- 50-80 kg. 5.Height 140-160 cm.

Exclusion criteria

Exclusion criteria: 1.Allergy to study drugs. 2.Contraindications to spinal anaesthesia such as raised ICT,infection at injection site,space occupying lesions of brain and hypovolemia. 3.Parturients with hypertensive disorders of pregnancy,cerebrovascular,hepatic,renal,endocrinological disease.

Design outcomes

Primary

Measure	Time frame
1.Mean of number of boluses of Mephentermine and Norepinephrine required to treat hypotension. 2.Mean of Response % of systolic blood pressure after first bolus doses of Mephentermine v/s Norepinephrin.Timepoint: Just after spinal hyotension, At 1 minute till 5 minutes At 2 minute inteval till 15 minutes At 5 minute interval till 30 minutes	—

Secondary

Measure	Time frame
1.Mean of systolic blood pressure 2.Mean of diastolic blood pressure 3.Mean of mean arterial pressure 4.Mean of heart rate maternal 5.Mean of neonatal APGAR scores in both groups.Timepoint: Just after spinal hyotension, At 1 minute till 5 minutes At 2 minute inteval till 15 minutes At 5 minute interval till 30 minutes	—

Countries

India

Contacts

Public ContactDr Lalit Singh Salawat

SMS medical college jaipur

drsavita020@gmail.com8290969216

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026