Health Condition 1: N644- Mastodynia
Conditions
Interventions
Intervention1: Centchroman: 30 mg , once daily for 3 months
Control Intervention1: Tamoxifen: 10 mg , once daily for 3 months
Control Intervention2: Not applicable: Not applicable
Sponsors
Non-funded
Eligibility
Inclusion criteria
Inclusion criteria: 1. All female patients, aged >18 years 2. Patients, who have complain of mastalgia with or without breast fibroadenoma having persistent symptoms for more than 1 month after reassurance and supportive breast management. 3. Pain severity of >3/10 on visual analog scale.
Exclusion criteria
Exclusion criteria: 1. Acute inflammatory breast conditions (cellulitis , breast abscess) 2. suspicion of malignancy ( clinical or radiological) 3. Family history of breast and ovarian carcinoma 4. Contraindication to centchroman and tamoxifen —-- a.Pregnancy b.Polycystic ovarian diseases ( PCOD ) c.Cervical hyperplasia do d.Recent history or clinical evidence of jaundice or liver diseases e Conditions like, chronic illness such as tuberculosis, renal diseases, severe allergic states etc. f.Patients willing to conceive within six months. 5.History of chest trauma 6.Severe drug reaction to either centchroman or tamoxifen after starting treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The comparison of pain score in the mastalgia patients with or without fibroadenoma undergoing treatment with centchroman and tamoxifen with Visual analog scale at end of 3 month treatment. Timepoint: Visual analog scale at end of 3 month treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the response in size of fibroadenoma To compare patient satisfaction with likert scale Timepoint: Visual analog scale at end of 3 month treatment. | — |
Countries
India
Contacts
Public ContactRishik Dhawan
AIIMS JODHPUR
Outcome results
None listed