EFFECT OF DRUG INTRALIPID FOR HEART PROTECTION IN HEART SURGERY (CORONARY ARTERY BYPASS SURGERY) ; PROSPECTIVE RANDOMIZED CONTROL STUDY IN DEPARTMENT OF ANAESTHESIA , SMS MEDICAL COLLEGE JAIPUR

CARDIOPROTECTIVE EFFECT OF INTRALIPID IN OFF PUMP CORONARY ARTERY BY PASS SURGERY ; PROSPECTIVE RANDOMIZED CONTROL STUDY IN DEPARTMENT OF ANAESTHESIA , SMS MEDICAL COLLEGE JAIPUR - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059964

Enrollment

Registered

2023-11-17

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I20-I25- Ischemic heart diseases Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Intralipid 2ml/kg: Intralipid 2ml/kg will be started in iv infusion form 30 minutes prior to revascularization Control Intervention1: 0.9% Normal saline 2 ml/kg: 2ml/kg of 0.9% Normal s

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective off pump coronary artery by pass surgeries, Patients willing to give informed written consent, Patients of either sex, ASA Grade II & III, Age Groups-18-70 years, Weight between 40-70kg. Patients with ejection fraction > 40%

Exclusion criteria

Exclusion criteria: Patients with history of drug allergy to study drug, Patients with hyperlipidemia, pre-existing Renal or Hepatic dysfunction, Patients with combined valve and coronary surgery, ONCAB, redo cardiac surgery, uncontrolled hypertension, any disorder with immunological dysfunction (eg, malignancy or positive serological test for HIV) in last 6 months

Design outcomes

Primary

Measure	Time frame
Mean CK-MB level Mean Troponin T level Mean Serum Lipid level Mean Serum creatinine level Mean Total bilirubin level Hemodynamic parameters (HR, SBP, DBP, MAP, SPO2) Timepoint: T0- Baseline reading, before induction T1- 15 minutes after induction T2- Reading 30 minutes after initiation of intralipid T3- reading at ICU admission T4- Reading 6th hr after ICU admission T5- Reading 24th hr after ICU admission T6- Reading 48th hr after ICU admission	—

Measure

Time frame

Mean CK-MB level Mean Troponin T level Mean Serum Lipid level Mean Serum creatinine level Mean Total bilirubin level Hemodynamic parameters (HR, SBP, DBP, MAP, SPO2) Timepoint: T0- Baseline reading, before induction T1- 15 minutes after induction T2- Reading 30 minutes after initiation of intralipid T3- reading at ICU admission T4- Reading 6th hr after ICU admission T5- Reading 24th hr after ICU admission T6- Reading 48th hr after ICU admission

—

Secondary

Measure	Time frame
Side effects if any (Bradyarrythmia, Tachyarrythmia, Hypotension, drug allergy)Timepoint: T0- Baseline reading, before induction T1- 15 minutes after induction T2- Reading 30 minutes after initiation of intralipid T3- reading at ICU admission T4- Reading 6th hr after ICU admission T5- Reading 24th hr after ICU admission T6- Reading 48th hr after ICU admission	—

Countries

India

Contacts

Public ContactAnuradha Yadav

S.M.S Medical College, Jaipur

dranjumsaiyed@gmail.com9214021930

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026