Does ablation of genicular nerves (nerves around knee joint) with radiofrequency ablation technology provide more relief than traditional steroid joint injections for relief from pain in osteoarthritis of knee joint?

Comparison between radiofrequency ablation of genicular nerves and intraarticular steroids in patients with advance OA Knee : Prospective Randomized Study - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059963

Enrollment

Registered

2023-11-17

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Radiofrequency ablation of genicular nerves: The patient rested in a supine position under fluoroscopy (C-arm).The affected knee joint flexed to 15 degrees by putting a pillow under it.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of either sex with primary OA of one or both knees fulfilling diagnostic criteria for OA knee laid down by American College of Rheumatology 2. Kellgren-Lawrence (radiologic criterion) score of at least 3 3. Chronic knee pain with pain intensity of at least 4 out 10 on the NRS on most or all days for more than 3 months, resistant to conventional therapy including non-steroidal anti-inflammatory drugs, opioids, muscle relaxants, oral steroids, physical therapy and intra-articular injection. 4. In patients with bilateral knee OA, the most painful side will be studied. 5. Age 40-70 years

Exclusion criteria

Exclusion criteria: 1. Patients with secondary OA of knees (ie, rheumatoid arthritis or gouty arthritis) 2. Any knee treatment with steroids, methotrexate or azathioprine; previous RF ablation treatment for similar symptoms; intra-articular knee corticosteroid or hyaluronic acid injection in the past 3 months 3. active systemic or local infections at the site of proposed needle and electrode placement; 4. coagulopathy or other bleeding disorder; 5. cognitive deficit; unstable medical or psychiatric illness; 6. Previous knee joint replacement surgery.

Design outcomes

Primary

Measure	Time frame
Numerical pain rating scale Oxford knee score Timepoint: Day 1Baseline /First VisitBaseline assessment Day 2Second Visit First Diagnostic block 1 week from second visitThird Visit Intervention (RFA/ Intra articular injection) 2 weeks from interventionFourth Visit1st follow up 1 month from interventionFifth Visit2nd follow up 3months from interventionSixth Visit3rd follow up	—

Secondary

Measure	Time frame
timed up and go testTimepoint: Day 1 Baseline /First Visit Baseline assessment Day 2 Second Visit First Diagnostic block 1 week from second visit Third Visit Intervention (RFA/ Intra articular injection) 2 weeks from intervention Fourth Visit 1st follow up 1 month from intervention Fifth Visit 2nd follow up 3months from intervention Sixth Visit 3rd follow up	—

Countries

India

Contacts

Public ContactDr Vinay Goyal

All India Institute of Physical Medicine and rehabilitation

vinaygoyal80@gmail.com7045773329

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026