Health Condition 1: B998- Other infectious disease
Conditions
Interventions
Intervention1: Low dose vasopressin: Children with fluid refractory septic shock will be randomized in two groups and will receive either low dose vasopressin at 0.0005u/kg/min or placebo for 24 hrs
C
Sponsors
Post Graduate Institute of Medical Education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Children with fluid refractory septic shock
Exclusion criteria
Exclusion criteria: Age Post cardiac arrest or ongoing cardiopulmonary resuscitation Already on vasoactive drugs from referring hospital or prior to enrolment. Patients of diabetes insipidus (DI) or syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Patients with severe hyponatremia ( Chronic kidney disease Chronic liver disease Refused consent by the parents/guardians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of shockTimepoint: 6 hr | — |
Secondary
| Measure | Time frame |
|---|---|
| Shock resolution at 1 and 4 hours of enrolment. Time (in hours) to achieve the therapeutic endpoints of shock resolution. Pediatric Logistic Organ Dysfunction (PELOD) score Vasoactive inotrope score (VIS) Vasoactive free days at day 28 PICU free days at day 28 In-hospital mortality Timepoint: 1 hr,4hr, 24 hr, 28 days | — |
Countries
India
Contacts
Public ContactDr Suresh Angurana
Post Graduate Institute of Medical Education and Research Chandigarh
Outcome results
None listed