Effect of exercise training in head and neck cancer patients

Impact of exercise based rehabilitation on chemo-radiation therapy induced complications in head and neck cancer - A Randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059839

Enrollment

Registered

2023-11-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C140- Malignant neoplasm of pharynx, unspecified

Interventions

Intervention1: Combined aerobic and resistance training: Aerobic exercises in the form of brisk walking and strength training with Thera bands. 3 sets of five reputations for 5 days per week. Control

Eligibility

Inclusion criteria

Inclusion criteria: Patients with head and neck cancer (stage III & IV a & IV b) receiving CRT with Eastern Cooperative Oncology Group (ECOG) score <2.

Exclusion criteria

Exclusion criteria: 1 Patients contraindicated to combined aerobic and resistance training 2 Platelet count : 3 Hb count : 4 Patients with severe orthopaedic and neurological problems. 5 Inability to comply with study procedures.

Design outcomes

Primary

Measure	Time frame
1)Sarcopenia will be evaluated by: a)Skeletal Muscle Mass, assessed using Bio Impedance Analyser (BIA) b)Muscle strength (as hand grip strength) using JAMAR hand Dynamometer c)Physical performance by Time-up-and- go test (TUG) 2)Sleep quality will be assessed by: a)Urinary melatonin excretion by ELISA method b)Pitts Berg Sleep Quality Index 3)Systemic inflammation assessed using inflammatory markers: a)Serum C-Reactive Protein (CRP), immunoturbidometric method b)Serum Albumin, Bromo cresol green dye binding method c)CRP/albumin ratio(CAR), calculated d)Neutrophil-Lymphocyte ratio (NLR), based on determination of these tests using automated cell counter e)Platelet-Lymphocyte ratio (PLR), based on determination of these tests using automated cell counter Timepoint: Pre chemo-radiation day 1 and at the end of 7th week	—

Measure

Time frame

1)Sarcopenia will be evaluated by: a)Skeletal Muscle Mass, assessed using Bio Impedance Analyser (BIA) b)Muscle strength (as hand grip strength) using JAMAR hand Dynamometer c)Physical performance by Time-up-and- go test (TUG) 2)Sleep quality will be assessed by: a)Urinary melatonin excretion by ELISA method b)Pitts Berg Sleep Quality Index 3)Systemic inflammation assessed using inflammatory markers: a)Serum C-Reactive Protein (CRP), immunoturbidometric method b)Serum Albumin, Bromo cresol green dye binding method c)CRP/albumin ratio(CAR), calculated d)Neutrophil-Lymphocyte ratio (NLR), based on determination of these tests using automated cell counter e)Platelet-Lymphocyte ratio (PLR), based on determination of these tests using automated cell counter Timepoint: Pre chemo-radiation day 1 and at the end of 7th week

—

Secondary

Measure	Time frame
4) Quality of life, assessed by the FACT-H&N scale. 5) Fatigue is assessed by Brief Fatigue Inventory Scale 6) Functional Capacity: using a six -minute walk test. Timepoint: Pre Chemo-radiation day 1 and at the end of 7th week	—

Countries

India

Contacts

Public ContactCherishma DSilva

Father Muller Medical College Hospital

cheri8585@gmail.com9663558311

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026