A study to compare and evaluate efficacy of preoperative dose of oral Pregabalin versus oral Gabapentine on the duration of postoperative analgesia in patients undergoing elective Modified Radical Mastectomy under general anaesthesia

A prospective randomised comparative study of the effect of preemptive dose of oral Pregabalin versus oral Gabapentine on postoperative analgesia and total analgesic consumption in Radical Mastectomy under general anaesthesia. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059804

Enrollment

Registered

2023-11-14

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast

Interventions

Intervention1: Preemptive dose of oral Pregabalin: Administering the study drug-single dosage of tablet Pregabalin 150 mg orally with a sips of water to the participants 2 hour before the surgery . Co

Eligibility

Inclusion criteria

Inclusion criteria: All ASA grade I and II patients between 18 to 60 years age group with carcinoma breast posted for elective Modified Radical Mastectomy surgeries will be recruited for the study after obtaining written informed consent.

Exclusion criteria

Exclusion criteria: Patients with Cardiovascular, Respiratory, Renal and Neurological disorders Patients with coagulation abnormalities Patients with chronic pain conditions and taking analgesics Obesity (BMI >30kg/m2) Patients with history of psychiatric disorders or on anti-psychotic drugs Patients on oral anticoagulants, anti-epileptic drugs, opioids Patients with history of alcohol abuse Any known drug allergy to the study drugs

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the efficacy of single preemptive dose of oral Pregabalin versus oral Gabapentine on the duration of postoperative analgesia and total analgesic consumption in patients undergoing elective Modified Radical Mastectomy under general anaesthesiaTimepoint: 24 hours	—

Secondary

Measure	Time frame
To record the intraoperative hemodynamic changes at specified intervals with Pregabalin and Gabapentine premedicationTimepoint: 24 hours	—

Countries

India

Contacts

Public ContactVaishnavi S G

Mysore medical College and research institute

dineshgovindarao@gmail.Com7676775491

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026