Health Condition 1: K650- Generalized (acute) peritonitis
Conditions
Interventions
Intervention1: Albumin group: Patients in the intervention group will be receiving 20% albumin as an infusion at the rate of 10ml/hr to target serum albumin level of more than 3g/dl. Maximum volume t
Sponsors
All India Institute of Medical Sciences, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent 2. Within 24 hours of diagnosis of secondary peritonitis 3. Serum albumin level less than 3 g/dl
Exclusion criteria
Exclusion criteria: 1. History of allergy to albumin 2. Pregnant women 3. Presence of volume overload [ as assessed by the physician] 4.Conditions in which albumin is clinically indicated – Nephrotic syndrome Burns Intestinal malabsorption syndrome Severe liver cirrhosis [ Child Pugh score – C] Congestive heart failure [ NYHA class of 3 or 4 ]
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of albumin administration on organ function as defined by a delta Sequential Organ Failure Assessment score [SOFA].Timepoint: 1 week from the day of randomisation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hospital length of stay Timepoint: Undefinable;2. 28-day mortalityTimepoint: 28 days from the day of randomisation;3. Cumulative fluid balanceTimepoint: 1 week from the day of randomisation;4. Incidence of post operative complicationsTimepoint: 1 week from the day of randomisation;5. Feeding toleranceTimepoint: 1 week from the day of randomisation | — |
Countries
India
Contacts
Public ContactDr Balaji Nagarajan
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed