Effectiveness of oral midodrine drug in reducing vasopressor dependence among ICU patients with septic shock:A prospective Randomized Trial.

Impact of oral midodrine to liberate Icu patients from vasopressor infusion in septic shock:Aprospective Randomised control trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059796

Enrollment

110

Registered

2023-11-14

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R652- Severe sepsis

Interventions

Intervention1: Adding oral midodrine to intervention group: Adding Oral or through Ryles tube of midodrine tablet of 10 mg QID to intervention group till patient is become off from inotrope support

Eligibility

Inclusion criteria

Inclusion criteria: Septic shock patients on dual vasopressor support

Exclusion criteria

Exclusion criteria: CKD PREGNANCY PRE-EXISTING LOVER DISEASE BRADYCARDIA of Severe organic heart disease Known allergy to midodrine

Design outcomes

Primary

Measure	Time frame
Time is taken to de-escalate to a single low-dose vasopressor (defined as noradrenaline =0.15 µg/kg/min) after administration of oral midodrine or placebo.Timepoint: During the course of icu stay	—

Secondary

Measure	Time frame
1.Vasoactive inotropic score (VIS) score trend, recorded 6th hourly till the patient is off inotropic support. Timepoint: During the icu stay;2. Maximum VIS score during ICU stay. Timepoint: During the icy stay;3. Mean VIS during ICU stay. Timepoint: During icu stay;4. Time taken for complete weaning off from inotropic support (in hours). Timepoint: During the Icu stay;5. Length of ICU stay. Timepoint: During the Icu stay;6. Mortality during ICU stay,Timepoint: During the Icu stay	—

Measure

Time frame

1.Vasoactive inotropic score (VIS) score trend, recorded 6th hourly till the patient is off inotropic support. Timepoint: During the icu stay;2. Maximum VIS score during ICU stay. Timepoint: During the icy stay;3. Mean VIS during ICU stay. Timepoint: During icu stay;4. Time taken for complete weaning off from inotropic support (in hours). Timepoint: During the Icu stay;5. Length of ICU stay. Timepoint: During the Icu stay;6. Mortality during ICU stay,Timepoint: During the Icu stay

—

Countries

India

Contacts

Public ContactDr ANAS V P

PGIMER CHANDIGARH

drvsaini@gmail.com7087008119

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026